The sera of humans and mice also contain ‘natural’Īntibodies, which are present prior to the infection.Īlthough the roles of IgM have long been a subject of Rise in antigen-specific IgG, IgA and IgE antibodies. Of antigen-specific immunoglobulin (Ig)M, followed byĪffinity maturation, isotype switching, and the ensuing Immune response that is characterized by an early rise Locksley, 1996 Medzhitov and Janeway, 1997 CarrollĪnd Prodeus, 1998). Interactions between innate immune mechanisms andĪdaptive immune reactions are now widely viewed asĮssential for a normal immune response (Fearon and Keywords: Autoimmunity Bacterial infection Complement Immune response Immunoglobulin M Viral infection Newĭevelopments regarding the function of both immune IgM antibodies and natural IgM antibodies will be examined here. Mostly encoded by germline V gene segments and have low affinities but broad specificites to both foreign and self structures.
Predominantly produced by B1 cells, in the absence of apparent stimulation by specific antigens. The IgM-type antibodies differ from other classes of antibodies in that they are IgM antibodies constitute the major component of the natural antibodies and is also the first class of antibodies producedĭuring a primary antibody response. Role of natural and immune IgM antibodies in immune responsesĭepartment of Pathology, Har6ard Medical School, Building D2, 200 Longwood A6e., Boston, MA 02115, USA
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